The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1093879-46-9, name is 2-(6-Bromopyridin-2-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H6BrNO2
Into a mixture of 2-(6-bromopyridin-2-yl)acetic acid (54 mg, 0.24 mmol) and (2S,4R)-N-(2′-chloro-2-fluoro-[l, -biphenyl]-3-yl)-4-fluoropyrrolidine-2-carboxamide hydrochloride (91 mg, 0.24 mmol) in DMF (2 mL), TBTU (116 mg, 0.36 mmol) was added followed by DIEA (0.083 mL, 0.48 mmol) with stirring. After the reaction was finished, NaHCO3 solution (10 mL) was added and the resulting solid precipitation was collected by filtration, washed with water, and purified by silica gel column chromatography to afford (2S,4R)- 1 -(2-(6-bromopyridin-2-yl)acetyl)-N-(2′-chloro-2-fluoro-[ 1 , 1 ‘-biphenyl]-3 -yl)-4- fluoropyrrolidine-2-carboxamide (124 mg) (41).1H NMR (400 MHz, Chloroform-d) delta 9.33 – 9.18 (m, 1H), 8.21 (ddd, J = 1.7, 7.3, 8.7 Hz, 1H), 7.53 – 7.42 (m, 2H), 7.31 (dddd, J = 4.1, 7.3, 9.6, 12.7 Hz, 6H), 7.14 (td, J = 1.1, 8.0 Hz, 1H), 7.01 (ddd, J = 1.7, 6.8, 7.8 Hz, 1H), 5.30 (d, J = 53.0 Hz, 1H), 4.95 (dd, J = 7.1, 8.4 Hz, 1H), 4.13 (ddt, J = 1.7, 12.6, 19.7 Hz, 1H), 3.92 (d, J = 2.0 Hz, 2H), 3.67 (ddd, J = 3.5, 12.6, 33.0 Hz, 1H), 2.86 – 2.71 (m, 1H), 2.45 (dddt, J = 2.0, 8.4, 14.8, 21.8 Hz, 1H). LC (method A): =3.08 min. LC/MS (EI) mlz: [M + H]+ 534.
With the rapid development of chemical substances, we look forward to future research findings about 1093879-46-9.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
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