Synthetic Route of 1155847-42-9, Adding some certain compound to certain chemical reactions, such as: 1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine,molecular formula is C5H2BrClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1155847-42-9.
[00409] Intermediate 4 IB. 4-Chloro-3-fluoro-2-hydrazinylpyridine, 2HC1: In microwave vial was added toluene (3 mL) and purged with N2 for 5 min. tert-Butyl carbazate (128 mg, 0.950 mmol), Intermediate 101 A (200 mg, 0.950 mmol), Cs2C03 (310 mg, 0.950 mmol), DPPF (20 mg, 0.036 mmol), and Pd2(dba)3 (25 mg, 0.027 mmol) were added sequentially into the solution. The sealed tube was heated at 100 C for 12 h. The reaction was diluted with brine, and extracted with EtOAc (2x). The combined organic layer was concentrated in vacuo, yielding oily residue, which was purified by silica gel chromatography to provide tert-butyl 2-(4-chloro-3-fluoropyridin-2- yl)hydrazinecarboxylate (41 mg, 16%) as orange solid. MS(ESI) m/z: 262.1 (M+H) . To the solid was added EtOH (1 mL) and 4 N HCl in dioxane (4 mL) and the reaction mixture was stirred for 2 h at rt. The mixture was concentrated to dryness to the desired product. MS(ESI) m/z: 162.1 (M+H)+.
According to the analysis of related databases, 1155847-42-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.; WO2013/22818; (2013); A1;,
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