Application of 1003711-43-0, Adding some certain compound to certain chemical reactions, such as: 1003711-43-0, name is 2-Bromo-5-hydroxy-3-methylpyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1003711-43-0.
To a solution of (R)-methanesulfonic acid-3-[l-(3-isopropyl-[l,2,4]oxadiazol-5- yl)piperidin-4-yl]butyl ester (Preparation 3, 250mg, 0.72mmol) and 6-bromo-5-methylpyridin-3-ol (143mg, 0.76mmol) in DMF (5.OmL), under argon, was added potassium carbonate (200mg, 1.45mmol) and the mixture was heated in a sealed tube at 700C for 16h. The reaction was diluted with EtOAc and the resulting solution was washed with brine (2 x 5OmL), sat. NaHCO3 solution and water, then dried (Na2SO4). Removal of the solvent in vacuo afforded the title compound: RT = 4.60 min; m/z (ES+) = 439.1 [M + H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1003711-43-0, 2-Bromo-5-hydroxy-3-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; DUPREE, Tom, Banksia; FRY, Peter, Timothy; FYFE, Matthew, Colin, Thor; JEEVARATNAM, Revathy, Perpetua; KRULLE, Thomas, Martin; SCHOFIELD, Karen, Lesley; SMYTH, Donald; STAROSKE, Thomas; STEWART, Alan, John, William; STONEHOUSE, David, French; SWAIN, Simon, Andrew; WITHALL, David, Matthew; WO2010/103334; (2010); A1;,
Pyridine – Wikipedia,
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