Synthetic Route of 105170-27-2, Adding some certain compound to certain chemical reactions, such as: 105170-27-2, name is 2-Bromo-5-methoxypyridine,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105170-27-2.
Example 287A [1-(3,4-dichlorophenyl)cyclobutyl](5-methoxypyridin-2-yl)methanone A solution of 2.5M n-Butyl lithium (6.5 mL, 16.25 mmol) in hexanes plus anhydrous diethyl ether (50 mL) was chilled to -75 C., followed by the dropwise addition of 2-bromo-5-methoxypyridine (3.12 g, 16.59 mmol) in diethyl ether (5 mL). The brown solution was stirred for 1 hour, followed by the addition of 1-(3,4-dichlorophenyl)-cyclobutanecarbonitrile (3.0 g, 13.27 mmol) in diethyl ether (5 mL). The reaction was warmed to 0 C. while stirring for 2 hours. The reaction was quenched with 1N hydrochloric acid (100 mL) and the biphasic mixture was stirred for 1 hour at ambient temperature. Added 3N sodium hydroxide (100 mL) and extracted twice with EtOAc (200 mL). The combined organic phases was washed with brine, dried over Na2SO4, filtered, and concentrated. The residue was chromatographed on silica (0-100% EtOAc in heptane) to give Example 287A (4.046 g, 12.03 mmol, 91% yield) as a light yellow oil. MS (ESI+): m/z 336 (M+H). 1H NMR (500 MHz, CD3CN) delta 8.14 (d, J=2.9 Hz, 1H), 7.96 (d, J=8.8 Hz, 1H), 7.64 (d, J=2.1 Hz, 1H), 7.40 (d, J=8.3 Hz, 1H), 7.35 (dd, J=8.4, 2.1 Hz, 1H), 7.31 (dd, J=8.8, 2.9 Hz, 1H), 3.86 (s, 3H), 3.00-2.89 (m, 2H), 2.66-2.54 (m, 2H), 2.02-1.91 (m, 1H), 1.89-1.77 (m, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105170-27-2, 2-Bromo-5-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AbbVie Inc.; Bayburt, Erol K.; Clapham, Bruce; Cox, Phil B.; Daanen, Jerome F.; Dart, Michael J.; Gfesser, Gregory A.; Gomtsyan, Arthur; Kort, Michael E.; Kym, Philip R.; Schmidt, Robert G.; Voight, Eric A.; US2013/131036; (2013); A1;,
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