Related Products of 78607-36-0 , The common heterocyclic compound, 78607-36-0, name is 2-Chloro-3-iodopyridine, molecular formula is C5H3ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-chloro-3-iodopyridine (500 mg, 2.09 mmol) was placed under argon and dissolved in anhydrous 9 THF (10 ml). 10 Et3N (1.44 ml, 5 eq, 10 mmol) and 11 1-ethoxy-4-ethynylbenzene (365 mg, 1.2 eq, 2.5 mmol) were added, followed by 12 CuI (10 mg, 0.025 eq, 0.05 mmol) and 13 PdCl2(PPh3)2 (37 mg, 0.025 eq, 0.05 mmol). The dark brown mixture was stirred at r.t. for 3 h, before 14 water (20 ml) and 15 CH2Cl2 (20 ml) were added. The aqueous layer was extracted with CH2Cl2 and the organic extracts were washed with water and brine, dried over MgSO4 and concentrated. The crude product was purified by flash chromatography (PE:EtOAc 85:15) to afford the desired 26 compound (440 mg, 82%). 1H-NMR (300 MHz, CDCl3): 1.43 (t, J=7.0 Hz, 3H), 4.06 (q, J=7.0 Hz, 2H), 6.87 (d, J=8.8 Hz, 2H), 7.22 (dd, J=7.7, 4.8 Hz, 1H), 7.49 (d, J=8.8 Hz, 2H), 7.82 (dd, J=7.7, 1.9 Hz, 1H), 8.31 (dd, J=4.8, 1.9 Hz, 1H).
The synthetic route of 78607-36-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1; Dimanche-Boitrel, Marie-Therese; Bach, Stephane; Delehouze, Claire; Goekjian, Peter; Comte, Arnaud; (32 pag.)US2018/312502; (2018); A1;,
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