Adding a certain compound to certain chemical reactions, such as: 139585-48-1, 2-Chloro-5-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chloro-5-methoxypyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Chloro-5-methoxypyridine
(Step 6) Preparation of 8-(6-tert-butyl-1H-benzo[d]imidazol-2-yl)-4-(5-methoxypyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine [117] To a solution of 4-(5-tert-butyl-1H-benzo[d]imidazol-2-yl)benzene amine 3.1 g (10 mmol) in toluene 10 mL were added 2-chloro-5-methoxy pyridine 1.5 g (10 mmol), Pd(OAc)2 0.1 g (0.5 mmol) and 2,2?-bis(diphenylphosphino)-1,1?-binaphthyl 0.5 g (0.8 mmol) and Cs2CO3 4.6 g (14 mmol), followed by stirring at 90C for 12 hrs. The reaction mixture was cooled to room temperature, concentrated under reduced pressure, and diluted with ethylacetate. The product thus formed was washed with a saturated sodium bicarbonate solution and a saturated NaCl solution, dried over magnesium sulfate and concentrated in a vacuum. The residue was purified by column chromatography (developing solvent: ethylacetate/hexane=2/3) to give 3.5 g of the title compound (yield 85%).[118] 1H NMR(MeOD-d4) delta : 8.04(d,1H, J=3.0Hz), 7.79(dd, 2H, J=7.8, 1.5Hz), 7.67(d, 1H, J=1.7Hz), 7.56(d, 1H, J=8.6Hz), 7.38(m, 2H), 7.25(d, 1H, J=9.0Hz), 7.17(dd, 1H, J=8.1, 1.4Hz), 6.95(t, 1H, J=8.0Hz), 4.52(t, 2H, J=4.4Hz), 3.99(t, 2H, J=4.4Hz), 3.86(s, 3H), 1.41 (s, 9H)
The synthetic route of 139585-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; KIM, Ji Duck; YOON, Hong Chul; KIM, In Woo; CHO, Min Jae; LEE, In Young; LEE, Sang Ho; PARK, Eun Kyung; LIM, Kwon Jo; NAM, Sang Hyun; WO2012/50380; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem