Adding a certain compound to certain chemical reactions, such as: 18368-64-4, 2-Chloro-5-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18368-64-4, blongs to pyridine-derivatives compound. Recommanded Product: 2-Chloro-5-methylpyridine
1.0 g (7.8 mmol) 2-chloro-5-methylpyridine are stirred under reflux in 5.7 ml (5.9 g, 117.6 mmol) hydrazine hydrate for 12 h. 10 ml ethylene glycol monoethyl ether are added to the cooled reaction mixture and the solvent is then removed completely on a rotary evaporator. This working step is repeated twice, methylene chloride is then added to the residue, the precipitate is filtered off, the filtrate is concentrated in vacuo and the residue is dried in vacuo.Yield: 644 mg (67% of th.)LC-MS (Method 8): Rt=0.35 min; MS (ESIpos): m/z=124 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18368-64-4, its application will become more common.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2010/305085; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem