Reference of 10366-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10366-35-5, name is 2-Chloronicotinamide, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To an aqueous solution of Na2Se2 (prepared from selenium metal (1.00 g, 12.66 mmol) and NaBH4 (434 mg, 11.47 mmol) in 60 ml distilled water) was added a solution of 2-chloro-3-nicotinamide (2.00 g, 12.77 mmol) with stirring under a nitrogen atmosphere. The reaction mixture was refluxed for 2 h with stirring. After cooling to room temperature, product was extracted with a chloroform-methanol (3:1 ratio) mixture. The organic phase was separated, washed with sodium bicarbonate solution followed by water, dried over anhydrous sodium sulphate, and filtered. The filtrate was concentrated under vacuum and the residue was column chromatographed with chloroform-methanol (90:10) mixture. The solution on evaporation afforded yellow powder (yield 216 mg, 8%; due to degradation during column purification product yield was significantly reduced), m.p. 126-128 C. Anal. for C12H10N4O2Se2; Calcd: C, 36.02; H, 2.52; N, 14.00%. Found C, 34.64; H, 2.73; N, 13.47%. UV-vis (in MeOH) (lambdamax in nm): 326, 402. IR in KBr (upsilon cm-1): 3250 (NH2), 1671 (CO). 1H NMR (dmso-d6) delta: 7.28 (d, d, 6 Hz, CH-5, py); 8.35, 7.84 (NH2); 8.16 (d, 7.5 Hz, py); 8.49 (d, 5 Hz, py); 13C{1H} NMR (dmso-d6) delta: 119.7, 128.1 (C-Se),135.5, 151.5, 160.5 (C-3, py); 168.2 (CO). 77Se{1H} NMR (dmso-d6) delta: 525 ppm. Mass (m/z): 400 (M+).
According to the analysis of related databases, 10366-35-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Parashiva Prabhu; Phadnis, Prasad P.; Wadawale, Amey P.; Indira Priyadarsini; Jain, Vimal K.; Journal of Organometallic Chemistry; vol. 713; (2012); p. 42 – 50;,
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