Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 59290-81-2
ED-14a (1.01 g, 5.52 mmol) is placed in tBuOU (50 mL), combined with DPPA (1.8 mL, 8.35 mmol) and NMM (724 muL, 6.59 mmol) and refluxed for 15 h. After cooling, saturated sodium chloride solution is added and the mixture is extracted several times with EE. The combined organic phases are washed with saturated sodium chloride solution, dried on MgSO4, filtered and evaporated down using the rotary evaporator. The residue is taken up in some water and freeze-dried. The Z-4a thus obtained (HPLC-MS: tRet. = 1.73 min; MS (M+H)+ = 254) is used without further purification.
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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STEURER, Steffen; ETTMAYER, Peter; MANTOULIDIS, Andreas; WO2010/34838; (2010); A2;,
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