Application of 100-26-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-26-5 as follows.
Step 1. Dimethyl pyridine-2.5-dicarboxylate SOCI2 (855 g, 7.2 mol) was added dropwise into the solution of pyridine-2,5-dicarboxylate (500 g, 3.0 mol) in MeOH (5 L) at room temperature. The mixture was stirred at 70 C overnight. After cooling, the mixture was evaporated, and the residue was added EA (5 L), followed by Na2C03 (sat.) until PH>7. The mixture was separated and the aqueous layer was extracted with EA (1 L*3). The combined organic layer was washed with brine, dried over Na2SC>4, filtered and concentrated to give dimethyl pyridine-2,5-dicarboxylate. The product was used for next step without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-26-5, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph, A.; ALHASSAN, Abdul-Basit; ANAND, Rajan; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; YU, Wensheng; YU, Younong; LIU, Shilan; WU, Hao; YANG, Chundao; (120 pag.)WO2016/109215; (2016); A1;,
Pyridine – Wikipedia,
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