With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3796-23-4, name is 3-(Trifluoromethyl)pyridine, molecular formula is C6H4F3N, molecular weight is 147.1, as common compound, the synthetic route is as follows.HPLC of Formula: C6H4F3N
General procedure: Add 3-trifluoromethylpyridine (73.6g, 0.5mol) and WCl6 (9.9g, 0.025mol) to a 250mL three-necked flask, purge nitrogen into the flask, heat with stirring to 120 C, and wait for the temperature to stabilize after nitrogen Switch to chlorine gas (100 mL / min), and react for 15 hours at 120 C with chlorine gas bubbling, stop heating, and switch the chlorine gas to nitrogen again to end the reaction.The temperature was then raised to 200 C and the entire product was distilled off. A 10 wt% NaOH solution was added to the steamed product to neutralize it, and extraction and liquid separation were performed to obtain an oily product.The obtained oily product was dried with anhydrous sodium sulfate and weighed 96.0 g.Qualitative analysis was performed by GC-MS, and quantitative analysis was performed by internal standard method of gas chromatography.The results are shown in Table 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3796-23-4, 3-(Trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Zhejiang Lantian Environmental Protection Gao Technology Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Yan Bo; Yu Wanjin; Lin Shengda; Liu Minyang; Liu Wucan; Zhang Jianjun; (10 pag.)CN110627711; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem