Synthetic Route of 53937-02-3, Adding some certain compound to certain chemical reactions, such as: 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone,molecular formula is C12H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53937-02-3.
General procedure: To a stirred degassed mixture of 8a (502 mg, 2.0 mmol), 4a (470 mg, 2.0 mmol), and K2CO3 (552 mg, 4.0 mmol) in dioxane (15 mL) were added CuI (76 mg, 0.4 mmol) and trans-N,N’-dimethyl-cyclohexane-1,2-diamine (56 mg, 0.4 mmol). The reaction vessel was sealed and heated at 110 C for 16 h. The reaction mixture was cooled to rt and concentrated. The resulting residue was diluted with DCM (250 mL), washed with brine (100 mL), dried over Na2SO4, and concentrated. The residue was purified by column chromatography (silica gel, DCM/MeOH = 97/3 to 96/4) to give the title compound (150 mg, 18%) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 53937-02-3, 4-Benzyloxy-2-(1H)-pyridone, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Igawa, Hideyuki; Takahashi, Masashi; Shirasaki, Mikio; Kakegawa, Keiko; Kina, Asato; Ikoma, Minoru; Aida, Jumpei; Yasuma, Tsuneo; Okuda, Shoki; Kawata, Yayoi; Noguchi, Toshihiro; Yamamoto, Syunsuke; Fujioka, Yasushi; Kundu, Mrinalkanti; Khamrai, Uttam; Nakayama, Masaharu; Nagisa, Yasutaka; Kasai, Shizuo; Maekawa, Tsuyoshi; Bioorganic and Medicinal Chemistry; vol. 24; 11; (2016); p. 2486 – 2503;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem