With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1620-76-4, name is 4-Methylpicolinonitrile, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives
A solution of 2-cyano-4-methyl pyridine (0.15 g, 1.27 mmol) in about 10 mL of 6 M HCl was heated under reflux for 24 h. During this time, the initially light yellow solution changed to a clear solution. The solution was evaporated to dryness to leave a white solid. The solid was recrystallized from a minimal amount of distilled water to give a yield of 148 mg (85 %) . 1H NMR (DMSO-dff) : delta = 8.65 (IH, s), 8.06 (IH, s), 7.66 (IH, s) 2.05 (3H, s)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-76-4, 4-Methylpicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; THE UNIVERSITY OF WARWICK; SADLER, Peter, John; PEACOCK, Anna, Frances, Acushla; VAN RIJT, Sabine, Helena; HABTEMARIAM, Abraha; WO2008/17855; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem