Adding a certain compound to certain chemical reactions, such as: 477871-32-2, 6-Amino-5-bromonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Amino-5-bromonicotinonitrile, blongs to pyridine-derivatives compound. Safety of 6-Amino-5-bromonicotinonitrile
Step 2; 5-Bromo-6-chloro-nicotinonitrile; To a solution of anhydrous CuCl2 (77 mg, 0.58 mmol) in CH3CN (3 mL) add tert- BuONO (0.72 mmol). Heat the mixture at 65C and then add a suspension of the intermediate above (96 mg, 0.48 mmol) in CH3CN (2 mL). Stir the mixture for 3 hours. Cool at room temperature. Pour into HCI 3M and extract with EtOAc. Dry the organic layer over Na2SO4. Eliminate the solvent. Purify by flash chromatography on silica gel (eluent: hexane/EtOAc 2/1) to afford the title compound (55 mg, 55%). ‘H-NMR (DMSO, 300 MHz): 8.93 (s, 1H), 8.90 (s, 1H).
The synthetic route of 477871-32-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/90337; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem