If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H5F3N2
EXAMPLE 824-(Aminomethyl)-l-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-N-(6-(trifluoromethyl)pyridin-3- yl)piperidine-4-carboxamide82A. ferf-Butyl 4-cvano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate; 6-(Trifluoromethyl)pyridin-3 -amine (319 mg, 1.97 mmol) was added in one portion to 1- (t°t-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (500mg, 1.97 mmol), HATU (822 mg, 2.16 mmol) and DIPEA (1030 mul, 5.90 mmol) in DMA (9832 mul) at 2O0C under nitrogen. The resulting solution was stirred at 20 0C for 24 hours. The reaction mixture was diluted with EtOAc (10ml), and washed sequentially with water (2 x 10ml) and saturated brine (10ml). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 10 to 50% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford tert-butyl 4-cyano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate (330 mg, 42.1 %) as a white solid .IH NMR (400.132 MHz, DMSO) delta 1.42 (9H, s), 1.97 – 2.05 (2H, m), 2.22 (2H, d), 3.00 (2H, s), 4.07 (2H, d), 7.93 (IH, d), 8.34 – 8.36 (IH, m), 8.97 (IH, d), 10.72 (IH, s)MS m/e MH+ 397
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem