As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68957-50-6, name is 5-Bromo-6-methyl-3-nitropyridin-2-amine, molecular formula is C6H6BrN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 68957-50-6
To a mixture of 5-bromo-6-methyl-3-nitro-pyridin-2-amine (1.0 g, 4.310 mmol) and copper cyanide (0.579 g, 6.464 mmol) in dimethyl sulfoxide (21.5 mL) was added dropwise in 10 minutes isopentyl nitrite (1.49 mL, 10.774 mmol) at 40C under argon. The mixture was stirred at 40C for 3 hours. The crude mixture was added slowly to a cold stirred solution of ethyl acetate and brine under argon flow, with a NaOCI trapper exit. A precipitate appeared and the mixture was cooled to room temperature and flushed with argon. The mixture was filtered over a pad of celite, washed with ethyl acetate. The filtrate aqueous phase was separated and extracted with ethyl acetate. The combined organic layers were washed with NaOCI and brine, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to give 827mg of crude 5-bromo-6-methyl-3-nitro-pyridine-2-carbonitrile. This material was used without further purification. LCMS (method 1 ): 240/242 (M-H) , retention time 1.17 min
With the rapid development of chemical substances, we look forward to future research findings about 68957-50-6.
Reference:
Patent; SYNGENTA CROP PROTECTION AG; MUEHLEBACH, Michel; EDMUNDS, Andrew; RENDLER, Sebastian; EMERY, Daniel; SEN, Indira; SIKERVAR, Vikas; (0 pag.)WO2019/234160; (2019); A1;,
Pyridine – Wikipedia,
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