Application of 28733-43-9, Adding some certain compound to certain chemical reactions, such as: 28733-43-9, name is 5-Bromonicotinamide,molecular formula is C6H5BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28733-43-9.
To a solution of NaOH (22.9 g, 572 mmol) in water (245 mL) at 0-5 C. (ice salt bath) was added bromine (9.44 mL, 184 mmol) maintaining the temperature at 0-5 C., to produce a sodium hypobromite solution. To this NaOBr-sol. was added commercially available 3-bromonicotinamide (30.15 g, 150 mmol) all at once with vigorous stirring. After being stirred for 15 min, the solution is clear and mixture was heated to 70-75 C. for 45 min. Cooled to 23 C., saturated with solid NaCl, extracted with TBME/THF (3×300 mL), dried over Na2SO4. Removal of the solvent in vacuum gave a dark brown oil which was purified by silica gel column chromatography with heptane/EtOAc 1:1?2:3 to give the title compound as a brown solid (16.036 g, 62%). MS (ISP) 173.1 [(M+H)+], 175.2 [(M+2+H)+].
According to the analysis of related databases, 28733-43-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; McArthur, Silvia Gatti; Goetschi, Erwin; Palmer, Wylie Solang; Wichmann, Juergen; Woltering, Thomas Johannes; US2006/217387; (2006); A1;,
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