As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52687-85-1, name is Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride, molecular formula is C7H7ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
The starting material can be manufactured as follows: A hot solution of 80 g (2 moles) of sodium hydroxide in 200 ml of water is added in portions, while stirring, to a mixture of 341 g (2 moles) of the hydrochloride of imidazo[1,2-a]pyridin-2(3H)-one in 700 ml of water. Then, a solution of 250.7 g (2.16 moles) of maleic acid in 600 ml of water is added dropwise in such a manner that the internal temperature of the reaction mixture remains between 40 and 45 C. After 30 hours at room temperature (20-25 C.) the mixture is cooled to 5 C., the resulting precipitate is filtered off, the filtrate is concentrated in vacuo to approximately half its volume, and the resulting product is filtered with suction. The combined residues are washed with a little cold methanol and dried in vacuo at 50 C. 400 g of 3-(1,2-dicarboxyethyl)-imidazo[1,2-a]pyridin-2(3H)-one having a melting point of 193 (decomposition) are obtained.
With the rapid development of chemical substances, we look forward to future research findings about 52687-85-1.
Reference:
Patent; Ciba-Geigy Corporation; US4426380; (1984); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem