Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53554-20-4, name is 6-Amino-2-chloronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 6-Amino-2-chloronicotinonitrile
6-Amino-2-chloronicotinonitrile (250 mg, 1.628 mmol), 1- (methylsulfonyl)piperazine, HC1 (1307 mg, 6.51 rnmo]) and potassium carbonate (675 mg, 4.88 mmol) were suspended in DMA (5426 m). The reaction mixture was heated to 105 C overnight, cooled to rt and stirred for 72 h. The reaction ws decanted into a separatory funnel containing EtOAc and H20, rinsing the residual K2CO3 with EtOAc. The aqueous layer was extracted with EtOAc (2X) and the combined organics were washed with 10% LiCl solution before drying (MgS04) and concentrating to a cream solid to afford the titled product (461 mg, 85% purity, 86% yield). This material was used as is in the subsequent reactions. 1H NMR (4QQMHz, DMSO-d6) d 7.52 (d,.1 8.4 Hz, 1 1 1). 6 83 (br s, 2H), 6.46 (d, 1=8.7 Hz, 1H), 5.99 (d, J=8.4 Hz, 1H), 3.68 – 3.54 (m, 4H), 3.27 – 3.12 (m, 4H), 2.92 (s, 3H); LC/MS [M+H] = 282.2; LC RT 0.63 min; (Column: BEH 08 2.1 x 50mm; Mobile Phase A: water with 0.05% TFA; Mobile Phase B: acetonitrile with 0.05% TFA; Temperature: 50 C; Gradient: 2-98% B over 1.7 min; Flow: 0.8 mL/min).
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; TARBY, Christine M.; NORRIS, Derek J.; LO, Julian C.; AHUJA, Vijay T.; SEITZ, Steven P.; GAVAI, Ashvinikumar V.; TOKARSKI, John S.; RAJASAGI, Mohini; WICHROSKI, Michael; BROEKEMA, Matthias; (155 pag.)WO2019/213340; (2019); A1;,
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