The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C12H11NO2
A mixture of 4-benzyloxy-2(lH)-pyridone (50 mg, 0.0025 mol), 2-bromo-5-iodotoluene (1.13 g, 0.0038 mol), CuI (0.238 g, 0.0015 mol), N,N-dimethylethylenediamine (0.266 ml, 0.0025 mol), and K3PO4 (1.06 g, 0.005 mol) in dioxane/DMF 9:1 (75 ml) was stirred at 180 0C in a microwave for 15 minutes Then, DCM was added. The solid was filtered off through dicalite and the filtrate was washed with NH4OH 32 %. The organic layer was separated, dried over Na2SO4 and the solvent was evaporated. The residue was purified by column chromatography (eluent: DCM). The desired product was collected and evaporated. The resulting product was precipitated with DIPE yielding 0.737 g of intermediate compound 1-11 (80 %).
With the rapid development of chemical substances, we look forward to future research findings about 53937-02-3.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/68265; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem