Adding some certain compound to certain chemical reactions, such as: 53939-30-3, name is 5-Bromo-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53939-30-3. 53939-30-3
2-chloro-5-bromopyridine (4.0 mmol) was added to CHC13 (40 mL), stirred under nitrogen, and BPO (0.08 mmol) and NBS (4.4 mmol) were added to the mixture. The reaction was heated to reflux for 5 h and cooled.The solvent was distilled off under reduced pressure to give a crude product.A solution of morpholine (0.50 mol) in ethanol was added to the crude product of the previous step under nitrogen and stirred at room temperature overnight.The solvent was removed under reduced pressure.The crude product was purified by column chromatography to give 4-(4-bromo-2-fluorophenyl)morpholine.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53939-30-3.
Reference:
Patent; Ocean University of China; Shao Changlun; (69 pag.)CN108658937; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem