Related Products of 54-92-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54-92-2, name is N’-Isopropylisonicotinohydrazide, molecular formula is C9H13N3O, molecular weight is 179.22, as common compound, the synthetic route is as follows.
General procedure: To a solution of the 4a (1g, 3.48 mmol), N’-isopropylbenzohydrazide (7a) (0.93g, 5.22 mmol) and HATU (1.98g ,5.22 mmol) in DMF (15.0 mL) was added N,N-diisopropylethylamine (DIPEA) (0.90 ml, 5.22 mmol). The reaction mixture was then stirred at room temperature overnight, and then partitioned between ethyl acetate and water. The organic phase was washed with brine dried over MgSO4, and concentrated. Purification by silica gel column chromatography using n-Hexane:EtOAc=3:1 as eluting solvents gave compound 8a as white solid. Compounds 8a-y, 14a-d, 15, 18, 20a and 20b were also prepared using same procedure.
The chemical industry reduces the impact on the environment during synthesis 54-92-2, I believe this compound will play a more active role in future production and life.
Reference:
Article; Kim, Minkyoung; Kwon, Jinsun; Kim, Mun Ock; Singh, Sarbjit; Kim, Sang Kyum; Lee, Kyeong; Lee, Kiho; Lee, Hyun Sun; Choi, Yongseok; Bulletin of the Korean Chemical Society; vol. 36; 2; (2015); p. 628 – 635;,
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