Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5407-87-4, name is 2-Amino-4,6-dimethylpyridine. A new synthetic method of this compound is introduced below., name: 2-Amino-4,6-dimethylpyridine
to a 100 mL 3 -necked round-bottom flask was placed 4,6-dimethylpyridin-2-amine (1.0 equiv, 19.6 mmol, 2.4 g) and DCM (20 mL). The reaction system was cooled down to -50 C in a liquid nitrogen bath, and l,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (1.0 equiv, 19.6 mmol, 5.6 g) was added. The resulting solution was stirred at -50 C for 30 min and gradually warmed to 25 C in 30 min. The reaction mixture was quenched with saturated NaHCO, (20 mL) and extracted withdichloromethane (2 x 20 mL). The organic layers were combined and concentrated under vacuum to afford 3.2 g (81.0%) of 5-bromo-4,6-dimethylpyridin-2-amine as an off-white solid. (M+H)+= 200.8, 202.8
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Reference:
Patent; CRINETICS PHARMACEUTICALS, INC.; ZHAO, Jian; WANG, Shimiao; ZHU, Yunfei; (212 pag.)WO2019/157458; (2019); A1;,
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