As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, molecular formula is C7H10ClNOS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride
Method AIn a 2 ltr 4-necked flask equipped with a thermometer and mechanical stirrer, Tert.- butyldimethylsilylchloride (90 g, 0.60 moles) was added slowly in a mixture of 5,6,7,7a-Tetrahydro-4H-thieno-[3,2-c]- pyridone-2 hydrochloride (100 g, 0.52 moles) and triethyl amine (56 g 0.55 moles) in dichloromethane (300 ml) at 0 +/-5 C under nitrogen atmosphere. Stir the reaction mass for 4 to 6 hrs at 20 +/-5 C. Slowly add 2- Fluoro-a-cyclopropyl carbonylbenzyl bromide (148 g, 0.58 moles) and triethyl amine (101 g, 1.0 moles) and stir the reaction mass for 20 to 24 hrs. Reaction mass quench into water and product extract with dichloromethane. Organic layer wash with 10% sodium chloride solution then water. Organic layer dried over sodium sulafate and recover the solvent under vacuum. Product crystallized in methanol. Filter the product and slurry washed methanol, and Dry the material under vacuum at 40-45 C to obtain 2-(tert-Butyldimethylsilyloxy)-5-(a-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7- tetrahydrothieno[3,2-c]-pyridine (140 g, 99.5%).
With the rapid development of chemical substances, we look forward to future research findings about 115473-15-9.
Reference:
Patent; MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus; WO2012/1486; (2012); A1;,
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