Electric Literature of 913090-41-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.913090-41-2, name is 6-(Difluoromethyl)pyridin-3-amine, molecular formula is C6H6F2N2, molecular weight is 144.1221, as common compound, the synthetic route is as follows.
A solution of the compound obtained in Step D (2.1 g) and JV-bromo- succinimide (2.56 g) in acetonitrile (50 ml) was stirred at 00C for 10 minutes. The reaction mixture was poured into water and extracted several times with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and then concentrated in vacuo. Chromatography on silica gel (eluent: hexane / ethyl acetate 1 : 1) afforded 2-bromo-6- difluoromethyl-pyridin-3-yl-amine (2.5 g) as a solid. MS (ES+) 223 / 225 (MH+); IH NMR (400 MHz, CDCl3) 4.38 (br s, 2H), 6.52 (t, IH), 7.08 (d, IH), 7.41 (d, IH).
The chemical industry reduces the impact on the environment during synthesis 913090-41-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; PITTERNA, Thomas; CASSAYRE, Jerome Yves; CORSI, Camilla; MAIENFISCH, Peter; WO2010/9968; (2010); A1;,
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