In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2,4-Difluoro-5-nitropyridine
4-(2-Fluoro-5-nitropyridin-4-yl)morpholine. In a 50 mL round-bottom flask vial was dissolved 2,4-difluoro-5-nitropyridine (175.7 mg, 1.098 mmol) in tetrahydrofuran (5 mL) to give a tan solution. After cooling to -40C, morpholine (0.080 mL, 0.918 mmol) was added, followed by Et3N (0.256 mL, 1.83 mmol). The cloudy yellow mixture was stirred at-40 C – 0C for 3 h. The mixture was concentrated togive a yellow solid. The solid was purified by flash column chromatography on silica gel, eluting with 60% ethyl acetate/hexane, to afford the desired product (209 mg, 100%) as a yellow solid: 1H NMR (400 MHz, Chloroform- d) delta 8.60 (s, 1H), 6.42 (s, 1H), 3.96 – 3.81 (m, 4H), 3.33 – 3.18 (m, 4H);19F NMR (376 MHz, Chloroform-d) delta -61.42.
The synthetic route of 60186-15-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
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