Electric Literature of 6283-81-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6283-81-4, name is Ethyl 3-oxo-3-(pyridin-3-yl)propanoate, molecular formula is C10H11NO3, molecular weight is 193.2, as common compound, the synthetic route is as follows.
1 g (5 mmol) of ethyl 3-pyridylacetoacetate was weighed,2,6-dihydroxytoluene 0.64 g (5 mmol) in 100 mL eggplant vials,Then add 5mL of anhydrous ethanol,Ice bath drop concentrated H2SO4 2.5mL,N2 gas protection room temperature stirring reaction 4h,(Chloroform / methanol = 40/1) to give 0.8 g of a white solid, which was purified by column chromatography on a white solid, filtered, dried and purified by column chromatography.Yield 61.03%,
Statistics shows that 6283-81-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 3-oxo-3-(pyridin-3-yl)propanoate.
Reference:
Patent; Xi’an Jiaotong University; Li Yiping; Zhao Yang; Gao Yanjuan; Ma Ying; Jin Zhengyu; Hu Yanzhen; Wang Yawen; (23 pag.)CN106674176; (2017); A;,
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