Synthetic Route of 727356-19-6, Adding some certain compound to certain chemical reactions, such as: 727356-19-6, name is 2-Bromo-6-(chloromethyl)pyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 727356-19-6.
General procedure: 3-Bromo-4-nitro-1H-indazole 2 (1.0 g) and R1CH2Cl (0.8 g) were added to N,N-dimethylformamide (10 mL). Potassium carbonate (1.14 g) was added to the solution, and stirred at 25C for 24 hrs. The reaction mixture was extracted with ethyl acetate (20 mL, three times) and water (20 mL), and the organic layers thus obtained were pooled, dried over anhydrous magnesium sulfate, and subjected to vacuum filtration and vacuum distillation. The residue was purified using column chromatography to afford the desired compound (1.36 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 727356-19-6, 2-Bromo-6-(chloromethyl)pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kim, Yu-Yon; Choi, Jaeyul; Choi, Kyungjin; Park, Changhee; Kim, Young Hoon; Suh, Kwee Hyun; Ham, Young Jin; Jang, Sun Young; Lee, Kyu-Hang; Hwang, Kwang Woo; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 271 – 275;,
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