The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73335-64-5, name is 1-(5-Bromopyridin-3-yl)-N-methylmethanamine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 1-(5-Bromopyridin-3-yl)-N-methylmethanamine
Step B Tert-butyl((5-bromopyridin-3-yl)methyl)(methyl)carbamate (31b)To a stirred solution of 31a (1 g, 4.97 mmol) in methanol (10 mL) triethylamine (3.3 mL, 24.8 mmol ) was added at 0C followed by the drop wise addition of Boc anhydride (1.7 mL, 7.5 mmol). The reaction mixture was stirred overnight at room temperature under nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was diluted with ethyl acetate, successively washed with water and brine. The organic layer was dried over anhydrous Na2SO4, evaporated to dryness under reduced pressure to obtain 31b (800 mg) as colorless gummy mass. 1H NMR (400 MHz, CD3OD): delta 8.59 (d, J=1.80 Hz, 1H), 8.43 (d, J=1.50 Hz, 1H), 7.92 (t, J=2.00 Hz, 1H), 4.47 (s, 2H), 2.91 (s, 3H), 1.46 (s, 9H). Molecular Formula: C12H17Br2O2; LC- MS purity: 98.4%; Expected: 301.1; Observed: 301.1 (M).
With the rapid development of chemical substances, we look forward to future research findings about 73335-64-5.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth, Jay; SCOTT, Mark, E.; THOMPSON, Christopher, F.; ANTHONY, Neville; CAMMARANO, Carolyn, Michelle; BAKSHI, Raman, Kumar; MOHANTY, Subhendu, Kumar; KORAPALA, Chandra, Sekhar; LATTHE, Prashant, R.; KAMBAM, Vyjayanthi, N.; SARKAR, Sujit, Kumar; THATAI, Jayanth, Thiruvellore; WO2015/50798; (2015); A1;,
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