With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.82671-02-1, name is 2,6-Dichloro-5-fluoronicotinonitrile, molecular formula is C6HCl2FN2, molecular weight is 190.99, as common compound, the synthetic route is as follows.Recommanded Product: 2,6-Dichloro-5-fluoronicotinonitrile
Weigh 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (24.8 g, 130 mmol)Concentrated sulfuric acid (125 mL) was added to a 500 ml flask, and the mixture was heated to 62 C for 1 hour.After cooling to room temperature, the reaction solution was poured into ice water (800 mL) and ethyl acetate (300 mL×4).The organic phase was washed successively with water (100 mL), saturated sodium bicarbonate (100 mL) and brine (50 mL).Dry over anhydrous sodium sulfate.Filtered, the filtrate was dried,A pale yellow solid (27.0 g, 99.5%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,82671-02-1, 2,6-Dichloro-5-fluoronicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yu Chuan; Yang Chuanwen; Wang Jiancheng; Li Jing; Cao Shengtian; Wu Fangyuan; Zhang Yingjun; S ·geerdeman; (79 pag.)CN108690016; (2018); A;,
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