Adding a certain compound to certain chemical reactions, such as: 86873-60-1, 5-Chloro-2-picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-2-picolinic acid, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Chloro-2-picolinic acid
To a stirred solution of tert-butyl (l-aminopiperidin-4-yl)carbamate (500 mg, 2.32 mmol, 1.0 equiv) in DMF (05 mL) was added HATU (1763 mg, 4.64 mmol, 2.0 equiv) at RT and stirred for 10 minutes Then 5-chloropicolinic acid (365 rng, 2.32 mmol, 1.0 equiv) was added followed by the addition of DIPEA (1.2 mL, 6.96 mmol, 3.0 equiv). The resulting reaction mixture was allowed to stir at RT for overnight. Product formation was confirmed by LCMS. the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL c 2). The combined organic layer was washed with water (30mL), brine solution (30 mL x 2), dried over anhydrous sodium sulfate and concentrated under reduced pressure, to obtain tert-butyl (l-(5- chloropicolinamido)piperidin-4-yl)carbamate (500 mg, 60 % Yield) as an off white solid. LCMS 355.1 [M+H]+; i XMR (400 MHz. DMSO-cA) d 9.61 (s, 1 H), 8.66 (d, J=2.19 Hz, 1 H), 8.11 (dd, J==8.33, 2.19 Hz, 1 H), 7.99 id. =8.33 Hz, 1 H), 6.83 (d, ./ 7.02 Hz, 1 H), 3.23 (br. s., 1 H), 2.84 – 3.00 (m, 3 H), 2.62 – 2.84 (m, 2 H), 1 73 (d, J=l 1.40 Hz, 2 H), 1.47 – 1.66 (m, 2 H), 1 38 (s. 9 1 1}
The synthetic route of 86873-60-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRAXIS BIOTECH LLC; DELGADO OYARZO, Luz Marina; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BERNALES, Sebastian; CHAKRAVARTY, Sarvajit; (0 pag.)WO2019/236710; (2019); A1;,
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