Electric Literature of 87674-21-3, Adding some certain compound to certain chemical reactions, such as: 87674-21-3, name is 1-(3-Fluoropyridin-4-yl)ethanone,molecular formula is C7H6FNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87674-21-3.
[0378] 3-Fluoro-l-(2-bromo-4-pyridinyl)ethanone Hydrobromide (169). l-(3- Fluoro-4-pyridinyl)ethanone (168) (880 mg, 6.33 mmol) was dissolved in glacial acetic acid (20 mL) and treated with bromine (0.36 mL, 7.0 mmol) followed by HBr/AcOH (30% w/v, 1.4 mL, 7.0 mmol) at 5-10 0C. The reaction mixture was stirred at 20 0C for 3 h, it was then diluted with Et2O (100 mL) and the precipitate was filtered off, washed with Et2O and dried under high vacuum to afford the crude bromoketone 169 (1.65 g) as a pale yellow solid that was used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
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