Synthetic Route of 884495-01-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine, molecular formula is C5H3BrFNO, molecular weight is 191.99, as common compound, the synthetic route is as follows.
2.08 mL (26.0 mmol) Ethyl iodide and 1 .08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.C7H7BrFNO (M = 220.0 g/mol)ESI-MS: 220 [M+H]+ Rt (HPLC) : 1 .27 mm (method X)
The chemical industry reduces the impact on the environment during synthesis 884495-01-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem