Related Products of 89978-52-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89978-52-9 as follows.
A-mixture of-[2′-{[(4-fluorophenyl)methyl]oxy}-5′-(trifluoromethyl)-2-biphenylyl]boronic acid (98mg, 0. 25MOL), ethyl 2-bromo-4-pyridinecarboxylate (58mg, 0. 25MOL), potassium carbonate (276mg, 2MMOL) and tetrakis (TRIPHENYLPHOSPHINE) PALLADIUM (0) (29mg, 0. 025MOL) in 1: 1 toluene/ethanol (4ml) was stirred and heated at 90C under nitrogen for 2 hours. After cooling and dilution with diethyl ether/water the organic phase was separated, dried (magnesium sulphate) and evaporated. The residue was chromatographed on silica eluting with ethyl acetate/iso-hexane (1: 9) to give 81 mg of colourless gum. LC/MS t=4. 10, [MH+] 496.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89978-52-9, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39753; (2004); A2;,
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