Electric Literature of 932-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 932-35-4, name is 3-Hydroxypicolinonitrile. A new synthetic method of this compound is introduced below.
(1) A suspension prepared by adding 2.73 g of 2-cyano-3-hydroxypyridine to 60 mL of a mixed solution of acetonitrile/water=5/1 was cooled to 0 C. A reaction mixture prepared by adding 4.85 g of N-bromosuccinimide slowly to the suspension was stirred for 2 hours under a nitrogen atmosphere. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with brine, then dried, and concentrated in vacuo to give 5.39 g of a crude product of 6-bromo-2-cyano-3-hydroxypyridine
At the same time, in my other blogs, there are other synthetic methods of this type of compound,932-35-4, 3-Hydroxypicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; TEIJIN PHARMA LIMITED; KAWANA, Asahi; KANAZAWA, Chikashi; TERA, Masayuki; TAKAHASHI, Yoshimasa; IMAZEKI, Mariko; TAKAHASHI, Hiroyuki; TANOKURA, Akira; (51 pag.)US2016/39784; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem