With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.936342-91-5, name is 5-Bromo-2-(chloromethyl)pyridine hydrochloride, molecular formula is C6H6BrCl2N, molecular weight is 242.9285, as common compound, the synthetic route is as follows.Safety of 5-Bromo-2-(chloromethyl)pyridine hydrochloride
The title compound was prepared by the reaction of 2-butyl-l,3-diazaspiro[4.4]non-l-en- 4-one.HCl (0.250 g, 1.083 mmol) with 5-bromo-2-(chloromethyl)pyridine.HCl (0.263 g, 1.083 mmol), according to the method described for the synthesis of Intermediate 451a, to give a white solid (0.300 g, 76percent). LC-MS (Method H): 1.23 min, [M + H]+= 364.0; H NMR (DMSO-i) 5 ppm 8.63 (dd, / = 2.3, 0.8 Hz, 1H), 8.04 (dd, / = 8.2, 2.3 Hz, 1H), 7.24 (d, / = 8.2 Hz, 1H), 4.75 (s, 2H), 2.25 – 2.41 (m, 2H), 1.71 – 1.94 (m, 6H), 1.56 – 1.71 (m, 2H), 1.43 – 1.56 (m, 2H), 1.27 (dq, / = 15.0, 7.4 Hz, 2H), 0.81 (t, / = 7.2 Hz, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,936342-91-5, 5-Bromo-2-(chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
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