In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 94166-64-0, name is 2-Chloro-6-nitropyridine, the common compound, a new synthetic route is introduced below. Formula: C5H3ClN2O2
Preparation of N-(3-(4-(6-Nitropyridin-2-yl)piperazin-l- yl)propyl)cyclohexanecarboxamideN-(3-(Piperazin-l-yl)propyl)cyclohexanecarboxamide (128 mg, 0.50 mmol), and 2- chloro-6-nitropyridine (79 mg, 0.50 mmol) were dissolved in dry acetonitrile (8 ml) in a 10 mL microwave tube and diisopropylethylamine (87 muL·, 0.50 mmol) added. The mixture was stirred and then heated in the microwave oven at 120C for 60 min. TLC (5% MeOH-EtOAc) showed the presence of 2 close running products of Rf 0.16 and 0.10. The reaction mixture was evaporated under reduced pressure to give a brown residue that was purified by chromatography on silica gel eluting with a 0-10% methanol in ethyl acetate gradient. The product was further purified by semi-preparative HPLC using a gradient of 50-95% methanol in water over 20 min (at) 18 ml/min (Gemini C18, 11 OA, 150 x 21.2 mm, 5 muiotaeta; Rt 10.8 min) to give the product (37 mg, 19%).LCMS: calcd for C19H29N5O3, 375.2; found 376.1 [M+H] . and 13C NMR were consistent with the structure.Purity was 96% by HPLC (UV 254nm).
The synthetic route of 94166-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca; WO2011/150183; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem