Reference of 94446-97-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 94446-97-6, name is 2-Bromo-3-(bromomethyl)pyridine. A new synthetic method of this compound is introduced below.
Under argon and in anhydrous medium, the aminocompound 3 (340 mg, 1.25 mmol) was dissolved in DMF (10 mL). At 0 C, 60% NaH (73 mg, 1.5 mmol) was added slowly. The mixture was stirred for 30 min at 0 C. Then, 2-bromo3-bromomethylpyridine (Rebek et al., 1985) (380 mg, 1.5 mmol) in DMF (10 mL) was added. The mixture was stirred 4 h at room temperature. The solvent was removed in vacuo, and the residue was quenched with H2O (25 mL). The aqueous mixture was extracted with ethyl acetate (20 mL), and the combined organic extract was washed several times with H2O, then dried over MgSO4. After concentration under reduced pressure, the crude mixture was purified by flash chromatography over silica gel (eluent: petroleum ether, ethyl acetate, 1:1) to give compound 4 as a white solid (347 mg, 64%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94446-97-6, its application will become more common.
Reference:
Article; Boutin, Jean A.; Bouillaud, Frederic; Janda, Elzbieta; Gacsalyi, Istvan; Guillaumet, Gerald; Hirsch, Etienne C.; Kane, Daniel A.; Nepveu, Francoise; Reybier, Karine; Dupuis, Philippe; Bertrand, Marc; Chhour, Monivan; Le Diguarher, Thierry; Antoine, Mathias; Brebner, Karen; Da Costa, Herve; Ducrot, Pierre; Giganti, Adeline; Goswami, Vishalgiri; Guedouari, Hala; Michel, Patrick P.; Patel, Aakash; Paysant, Jerome; Stojko, Johann; Viaud-Massuard, Marie-Claude; Ferry, Gilles; Molecular Pharmacology; vol. 95; 3; (2019); p. 269 – 285;,
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