The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94446-97-6, name is 2-Bromo-3-(bromomethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Bromo-3-(bromomethyl)pyridine
PREPARATION 484-[(2-Bromo-3-pyridyl)methyl]morpholin-3-one; To a solution of 2-bromo-3-bromomethyl-pyridine (0.68 g, 2.36 mmol) in dimethylformamide (10 mL) are added sodium hydride (0.11 g, 60% suspension, 2.82 mmol), morpholin-3-one (0.20 g, 1.97 mmol) and tetrabutylammonium iodide (catalytic) at 0 C. The mixture is stirred at room temperature for 16 hours. After completion, the reaction mixture is partitioned between ethyl acetate (25 mL) and water (25 mL). The aqueous layer is extracted with ethyl acetate (2¡Á25 mL) and the combined organic extracts are dried over sodium sulfate and concentrated in vacuo. The crude material is purified by column chromatography over silica gel eluting with hexane/ethyl acetate (55:45) to yield 0.35 g (66%) of the title compound. MS (m/z): 271/273 (M+1, M+3).
With the rapid development of chemical substances, we look forward to future research findings about 94446-97-6.
Reference:
Patent; ELI LILLY AND COMPANY; US2011/118251; (2011); A1;,
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