Electric Literature of 55589-47-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55589-47-4, name is 3-Methylpicolinaldehyde, molecular formula is C7H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compound (104.9 mg) obtained in Example 47-3 was dissolved in methanol (3.2 ml) and then added with the compound (36.3 mg) obtained in Example 53-1 and sodium cyanoborohydride (31.4 mg). Then, the solution was adjusted to pH 5 with acetic acid and then stirred at room temperature for 14 hours. After completion of the reaction, a 1 mol/l sodium hydroxide aqueous solution was added to the reaction solution, followed by separation/extraction with chloroform. The organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate) and then treated with hydrochloric acid, thereby obtaining hydrochloride (91.5 mg) of the subject compound as a white solid. MS(FAB,Pos.)m/z=525[M+H]+1H-NMR(500MHz,DMSO-d6) :delta=0.88(6H,t,J=7.3Hz),1.60-1.80(4H,m),2.37(3H,s),2.95(4H,t,J=7.1Hz),3.84(2H,s),4.16(2H, s),4.25(2H,s),4.28(2H,s),7.53(2H,d,J=8.5Hz),7.55(2H,d,J=8.3H z),7.62(2H,s),7.76(1H,dd,J=4.8,7.6Hz),7.83(2H,d,J=8.5Hz),7.8 6(2H,d,J=8.3Hz),8.22(1H,d,J=7.6Hz),8.65(1H,d,J=4.9Hz).
According to the analysis of related databases, 55589-47-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
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