In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 588720-29-0, name is Imidazo[1,5-a]pyridine-7-carboxylic acid, the common compound, a new synthetic route is introduced below. Recommanded Product: 588720-29-0
To a 50 mL single neck RB flask starting 1H-Imidazol (1,5-a)pyridine-7-carboxylic acid (0.5 g, 3.086 mmol) was added, followed by ethyl ester of L-Leucine Hydrochloride (0.5 g, 3.086 mmol), HATU (0.323 g, 0.85 mmol) and DMF (8 mL). The contents were stirred for 5 mins. After clear solution formation DIPEA (1.1 mL, 6.172 mmol) was added and the reaction mass stirred for 16h at 20-30C. After 16h, the completion of the reaction was confirmed byTLC/LCMS, and worked-up. Ice-cold water (2OmL) was added slowly to the reaction mixture with stirring. The product was extracted with ethyl acetate (2x2OmL). The ethyl acetate extracts were separated washed with (1×20 mL) water, separated the organics, dried over anhydrous sodium sulphate and distilled off the volatiles under reduced pressure to get the crude product. This crude material was subjected to purification using preparative RP HPLC. The pure material thus obtained yielded 60-70% yield of the product of desired purity.
The synthetic route of 588720-29-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALKEM LABORATORIES LTD.; NAGARAJ, Harish Kumar Mysore; BANDODKAR, Balachandra S; RAVILLA, Lokesh; YELLAPU, Sudhakar; RUDRESHA, Ashok Seegebagi; SINGH, Jitendra Kumar; G, Vaidyanathan.; (95 pag.)WO2016/27285; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem