Electric Literature of 119308-57-5 ,Some common heterocyclic compound, 119308-57-5, molecular formula is C7H5Br2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of methyl 2,6 -dibromoisonicotinate (1 0.0 g, 33.91 mmol) in ethanol (200.0 ml) was slowly added NaBH 4 (6.4 g, 169.18 mmol) at room temperature under stirring. The reaction was heated to reflux and kept at reflux for 2 hours. The reaction solution was cooled to room temperature, and 2 M HCl ( 35.0 ml) was added slowly with stirring until the bubbling stopped. The ethanol was removed by rotary evaporation. Solid NaOH was added under stirring until the solution became basic. The solution continued to be stirred, and during stirring the product was precipitated. A white solid product was collected by filtration. After drying, the product was obtained in an amount of 5.Og (55.6%). 1H NMR (CDCl3): delta 7.44 (s, 2H, HPy), 4.70 (s, 2 H, OCH2). 13C NMR (CDCl3): delta155.05, 140.70, 124.15, 62.22. MS (EI) m/z (%): 266.8 (100%) [M +].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 119308-57-5, Methyl 2,6-dibromoisonicotinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Georgia Tech Research Corporation; SOLVAY (Societe Anonyme); WO2009/80799; (2009); A2;,
Pyridine – Wikipedia,
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