Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 945954-94-9, name is Methyl 6-bromo-3-methoxypicolinate. A new synthetic method of this compound is introduced below., Safety of Methyl 6-bromo-3-methoxypicolinate
A mixture of methyl 6-bromo-3-methoxypicolinate (4 g, 18.4 mmol) and LiOH- H20 (1.6 g, 36.9 mmol) in dioxane / H20 (5 / 1, 40 mL) was stirred at RT overnight. After pH was adjusted to 7, the mixture was filtered to provide crude 6-bromo-3-methoxypicolinic acid (3.1 g, yield: 81 %). 1H- MR (CDC13 , 400 MHz) delta 10.71 (m, 1H), 7.70 (d, J= 8.0 Hz, 1H), 7.40 (d, J= 8.0 Hz, 1H), 4.01 (s, 3H). MS (M+H)+: 232 / 234.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; HE, Shuwen; DAI, Xing; PALANI, Anandan; NARGUND, Ravi; LAI, Zhong; ZORN, Nicolas; XIAO, Dong; DANG, Qun; LI, Peng; PENG, Xuanjia; SOLL, Richard; WO2014/121418; (2014); A1;,
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