Related Products of 13602-11-4 ,Some common heterocyclic compound, 13602-11-4, molecular formula is C8H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
INTERMEDIATE 88- PREPARATION of methyl 6-(bromomethyl)picolinate. A mixture of methyl 6-methylpicolinate (1.81 g; 1 1.97 mmol) and carbon tetrachloride (60 ml_) was treated with /V-bromosuccinimide (2.37 g, 13.17 mmol) and benzoyl peroxide (0.299 g; 1.20 mmol) and heated at refluxing temperature for 21 hours. The resulting brown suspension was concentrated under reduced pressure and the residue purified by flash chromatography on silica gel (eluent 0 to 6% ethyl acetate in dichloromethane) to give 0.773 g (28%) of methyl 6-(bromomethyl)picolinate as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13602-11-4, its application will become more common.
Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D; REMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; ALLASIA, Sara; MARCHAND, Arnaud; KILONDA, Amuri; CHALTIN, Patrick; WO2012/80221; (2012); A1;,
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