《Efficient synthesis of dibenzazepine lactams via a sequential Pd-catalyzed amination and aldol condensation reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Song, Ha-Jeong; Yoon, Eunyoung; Heo, Jung-Nyoung. Quality Control of 2-Bromonicotinaldehyde The article mentions the following:
A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives e.g., I. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination and an aldol condensation. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromonicotinaldehyde