Song, J. H.; Bae, S. M.; Lee, E. J.; Cho, J. H.; Jung, D. I. published the artcile< Formation of benzodiazepines and pyrazinylquinoxalines from aromatic and heteroaromatic ketones via deoximation>, Quality Control of 350-03-8, the main research area is benzodiazepine preparation; pyrazinylquinoxaline preparation.
In the course of present investigations, it was found that dichloroamine T could be an efficient reagent for the conversion of oximes into the corresponding carbonyl compounds Herein the synthesis of 1H-1,5-benzodiazepine derivatives I [R = pyrrol-2-yl, 2-pyridinyl, 2-thienyl, etc.] from heteroaromatic ketones and acetone equivalent was obtained using dichloroamine-T. On the other hand, when diamine (1,2-phenylene diamine or 1,2-naphthalene diamine) with heterocyclic ketone (acetyl pyridine or acetyl pyrazines) in the presence of concentrate HCl and SiO2 was refluxed, quinoxaline derivatives, II [R = 2-pyrazinyl, 2-pyridinyl, 2-thienyl, etc.] as yellow crystalline solids were isolated in high yields.
Asian Journal of Chemistry published new progress about Benzodiazepines Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Quality Control of 350-03-8.