Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Name: Pyridine-3-sulfonyl chloride.
Song, Mengmeng;Zhang, Zhiguo;Zheng, Dan;Li, Xiang;Liang, Rui;Zhao, Xu-na;Shi, Lei;Zhang, Guisheng research published 《 Hypervalent organoiodine promoted dearylation reaction of N-aryl sulfonamides》, the research content is summarized as follows. An efficient Dess-Martin periodinane (DMP)-promoted dearylation of N-arylsulfonamides RS(O)2NHR1 (R = Ph, 2-naphthyl, 2-thienyl, etc.; R1 = quinolin-8-yl, 2-methylphenyl, 4-methylbenzyl, etc.) was developed through a highly selective oxidative cleavage of the inert C (aryl)-N bonds in secondary sulfonamides while leaving the S-N bond unchanged. This metal-free reaction proceeds under mild conditions and provides access to various biol. important primary sulfonamides, some of which are otherwise unattainable using conventional aminolysis and hydrolysis methods. The concise and efficient dearylation reaction provides the use of an aryl group as a removable protecting sulfonamide group under metal catalyst-free conditions.
Name: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.