The author of 《Impact of Pyridyl Moieties on the Inhibitory Properties of Prominent Acyclic Metal Chelators Against Metallo-β-Lactamase-Producing Enterobacteriaceae: Investigating the Molecular Basis of Acyclic Metal Chelators’ Activity》 were Sosibo, Sphelele C.; Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Bester, Linda A.; Ngila, Jane C.; Sun, Darren D.; Kumalo, Hezekiel M.. And the article was published in Microbial Drug Resistance (New Rochelle, NY, United States) in 2019. Computed Properties of C12H13N3 The author mentioned the following in the article:
Carbapenem-resistant Enterobacteriaceae (CREs)-mediated infections remain a huge public health concern. CREs produce enzymes such as metallo-β-lactamases (MBLs), which inactivate β-lactam antibiotics. Hence, developing efficient mols. capable of inhibiting these enzymes remains a way forward to overcoming this phenomenon. In this study, we demonstrate that pyridyl moieties favor the inhibitory activity of cyclic metal-chelating agents through in vitro screening, mol. modeling, and docking assays. Di-(2-picolyl) amine and tris-(2-picolyl) amine exhibited great efficacy against different types of MBLs and strong binding affinity for NDM-1, whereas 2-picolyl amine did not show activity at a concentration of 64 mg/L in combination with meropenem; it further showed the lowest binding affinity from computational mol. anal., commensurating with the in vitro screening assays. The findings revealed that the pyridyl group plays a vital role in the inhibitory activity of the tested mols. against CREs and should be exploited as potential MBL inhibitors. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3)
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Computed Properties of C12H13N3