In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87674-15-5, name is 1-(3-Fluoropyridin-4-yl)ethanol, the common compound, a new synthetic route is introduced below. Formula: C7H8FNO
a) 4-(l-Chloroethyl)-3-fluoropyridinel-(3-fluoropyridin-4-yl)ethanol (0.8 g, 5.7 mmol) was treated with thionyl chloride (5 mL) and the resulting mixture was heated to 80 C for 2 h. Water (10 mL) and sat. sodium bicarbonate (aq., 10 mL) was added. The product was extracted with DCM (three times). The combined organic extracts were washed with brine, dried over sodium sulphate and concentrated in vacuo. The crude product was purified by flash column chromatography (eluent heptane: ethyl acetate gradient) to yield 0.36 g (39% yield) of the title compound. 1H NMR (300 MHz, CDCl3) 8.45 (m, 2H), 7.50 (m, IH), 5.34 (q, IH), 1.83 (d, 3H).
The synthetic route of 87674-15-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2008/39138; (2008); A1;,
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