Reference of 1060805-69-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060805-69-7, name is 1-(4-Bromopyridin-2-yl)ethanone. A new synthetic method of this compound is introduced below.
Methyl 2-bromo benzoate (methyl-2-bromobenzoate) (1 eq.)Was dissolved in 180 mL THF, into the NaH (2 eq.) Was stirred for 30 minutes. After stirring, 1 – (4-bromo-2-yl) ethane-1-one (1- (4-bromopyridin-2-yl) ethan-1-one) was dropwise added (1 eq.) Slowly. Stirred for 2 hours at room temperature and heated at 100 16 hours. When the reaction is complete and then lower the temperature to room temperature, then extracted using ethyl acetate (ethyl acetate) and 1N HCl, aqueous NaHCO3, H2O. Purification separated by column chromatography to give a 12-1 after extraction.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060805-69-7, 1-(4-Bromopyridin-2-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; Hee Sung Material Co., Ltd; Lee, Hyun Ju; Kim, Gi Yeong; Lee, Do Hyung; Choe, Jin Sok; Uhm, Song Jin; Lee, Ju Dong; (46 pag.)KR2016/1537; (2016); A;,
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